Section 1

1. What is GERMLINE GENE EDITING?
   1. What are the pros?
   2. What are the cons?
2. What is SOMATIC CELL GENE EDITING?
   1. What are the pros?
   2. What are the cons?
3. Is either of these produced by nature?
   1. Describe.
4. How is gene editing going against Nature?

Section 2

1. How is autonomy related to GERMLNE GENE EDITING?
   1. Note: Future offspring have no say.
2. How is autonomy related to Somatic Cell gene Editing?
3. What is NATURAL SELECTION?
   1. What is the driving force for Natural Selection?
4. How has nature produced the best possible combination of traits for today’s environment?
5. How long has nature been working on optimizing the human genome?
6. Does the optimum human genome change with time?
   1. Explain.

Section 3

1. How are gene editing and gene drive changing Natural Selection?
2. What are ‘off-target effects of gene editing?
3. What are the roles/responsibilities of each of the following groups in the process of gene editing and gene drive?
   1. PUBLIC
   2. POLICYMAKERS
   3. SCIENTIFIC COMMUNITY

Section 4

1. What are the roles of the following in gene editing:
   1. Effectiveness
   2. Safety
   3. Reversibility
   4. Cost
2. Comment on the following:
   1. ‘gene editing should be to shape a child so she will have more advantages in life’
   2. ‘The prospective parents should be the ones to decide whether and how to create a child that best fits their desires.’
3. Has there been enough time in human evolution to prepare human parents to be able to make these decisions?